Chemicals and Drugs

Serotonin 5-HT1B Receptor

A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A serotonin receptor subtype found at high levels in the BASAL GANGLIA and the frontal cortex. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1D RECEPTOR. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigraine effect.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

26 entry terms
  • 5-HT(1B) Receptor
  • 5-HT(1Dbeta) Receptor
  • 5-HT1B Receptor
  • 5-HT1Dbeta Receptor
  • 5-Hydroxytryptamine 1B Receptor
  • 5-Hydroxytryptamine 1B Receptors
  • Receptor, 5-Hydroxytryptamine 1B
  • Receptor, Serotonin Type 1Dbeta
  • Receptor, Serotonin, 5-HT1B
  • Serotonin 1B Receptor
  • Serotonin 1D Beta Receptor
  • Serotonin 1Dbeta Receptor
  • Serotonin 1Dbeta Receptors
  • 1B Receptor, 5-Hydroxytryptamine
  • 1B Receptors, 5-Hydroxytryptamine
  • 5 HT1B Receptor
  • 5 HT1Dbeta Receptor
  • 5 Hydroxytryptamine 1B Receptor
  • 5 Hydroxytryptamine 1B Receptors
  • Receptor, 5 Hydroxytryptamine 1B
  • Receptor, 5-HT1B
  • Receptor, 5-HT1Dbeta
  • Receptor, Serotonin 1B
  • Receptor, Serotonin 1Dbeta
  • Receptors, 5-Hydroxytryptamine 1B
  • Receptors, Serotonin 1Dbeta

MeSH Record

Aspects Covered

17 allowable subheadings

Indexed with the subheadings administration & dosage, analysis, biosynthesis, blood, chemistry, classification, deficiency, drug effects, genetics, history, immunology, isolation & purification, metabolism, physiology, radiation effects, therapeutic use, ultrastructure.

MeSH Record

History Note

2004; use RECEPTOR, SEROTONIN, 5-HT1B (NM) 1993-2003

MeSH Record

Previous Indexing

  • Receptors, Serotonin (1993-2003)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.543w.750w.670w.800w.100w.150
  2. D12.776w.543w.750w.695w.800w.100w.150
  3. D12.776w.543w.750w.720w.670.100w.500
  4. D12.776w.543w.750w.720w.850w.100w.150

AMA Style

References

  1. National Library of Medicine. Serotonin 5-HT1B Receptor. Medical Subject Headings (MeSH). 2026. Unique ID D044302. http://id.nlm.nih.gov/mesh/2026/D044302
  2. Serotonin 5-HT1B Receptor. In: Wikidata. https://www.wikidata.org/wiki/Q24775311