Structured Summary
Abstract
A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
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Synonyms
9 entry terms
- LEKTI Protein
- Lympho-Epithelial Kazal-Type Inhibitor
- SPINK5 Protein
- Serine Protease Inhibitor Kazal-Type 5
- Inhibitor, Lympho-Epithelial Kazal-Type
- Kazal-Type Inhibitor, Lympho-Epithelial
- Lympho Epithelial Kazal Type Inhibitor
- Serine Peptidase Inhibitor Kazal Type 5
- Serine Protease Inhibitor Kazal Type 5
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2018
MeSH Record
Previous Indexing
- Carrier Proteins (1999-2017)
- Proteinase Inhibitory Proteins, Secretory (2005-2017)
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AMA Style
References
- National Library of Medicine. Serine Peptidase Inhibitor Kazal-Type 5. Medical Subject Headings (MeSH). 2026. Unique ID D000074163. http://id.nlm.nih.gov/mesh/2026/D000074163
- Serine Peptidase Inhibitor Kazal-Type 5. In: Wikidata. https://www.wikidata.org/wiki/Q21114782