Chemicals and Drugs

Sequestosome-1 Protein

A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

8 entry terms
  • EBI3-Associated Protein of 60 KDa
  • EBIAP Protein
  • Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
  • Ubiquitin-Binding Protein p62
  • EBI3 Associated Protein of 60 KDa
  • Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
  • Sequestosome 1 Protein
  • Ubiquitin Binding Protein p62

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2017

MeSH Record

Previous Indexing

  • Adaptor Proteins, Signal Transducing (1996-2016)
  • Heat-Shock Proteins (1996-2016)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.024w.329
  2. D12.776w.094.750
  3. D12.776w.157w.057w.160
  4. D12.776w.476.024w.422

AMA Style

References

  1. National Library of Medicine. Sequestosome-1 Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000071456. http://id.nlm.nih.gov/mesh/2026/D000071456
  2. Sequestosome-1 Protein. In: Wikidata. https://www.wikidata.org/wiki/Q21106590