Chemicals and Drugs

Separase

Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2014

MeSH Record

Previous Indexing

  • Cell Cycle Proteins (1999-2013)
  • Endopeptidases (1999-2013)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.656w.262w.500.792w
  2. D08.811w.277w.656w.300w.200.792w
  3. D12.776w.167.552w

AMA Style

References

  1. National Library of Medicine. Separase. Medical Subject Headings (MeSH). 2026. Unique ID D064247. http://id.nlm.nih.gov/mesh/2026/D064247
  2. Separase. In: Wikipedia. https://en.wikipedia.org/wiki/Separase
  3. Separase. In: Wikidata. https://www.wikidata.org/wiki/Q22676914