Diseases

Second Primary Neoplasms

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

70 entry terms
  • Metachronous Neoplasms
  • Metachronous Second Primary Neoplasms
  • Neoplasms, Metachronous
  • Neoplasms, Metachronous Second Primary
  • Neoplasms, Second Primary
  • Second Malignancy
  • Second Neoplasm
  • Second Primary Neoplasms, Metachronous
  • Malignancies, Second
  • Malignancy, Second
  • Metachronous Neoplasm
  • Neoplasm, Metachronous
  • Neoplasm, Second
  • Neoplasm, Second Primary
  • Neoplasms, Second
  • Second Malignancies
  • Second Neoplasms
  • Second Primary Neoplasm
  • Cancer, Second Primary
  • Neoplasms, Therapy-Associated
  • Neoplasms, Therapy-Related
  • Neoplasms, Treatment-Associated
  • Neoplasms, Treatment-Related
  • Second Cancer
  • Therapy-Associated Cancer
  • Therapy-Associated Neoplasms
  • Therapy-Related Cancer
  • Therapy-Related Neoplasms
  • Treatment-Associated Cancer
  • Treatment-Associated Neoplasms
  • Treatment-Related Cancer
  • Treatment-Related Neoplasms
  • Cancer, Second
  • Cancer, Therapy-Associated
  • Cancer, Therapy-Related
  • Cancer, Treatment-Associated
  • Cancer, Treatment-Related
  • Cancers, Second
  • Cancers, Second Primary
  • Cancers, Therapy-Associated
  • Cancers, Therapy-Related
  • Cancers, Treatment-Associated
  • Cancers, Treatment-Related
  • Neoplasm, Therapy-Associated
  • Neoplasm, Therapy-Related
  • Neoplasm, Treatment-Associated
  • Neoplasm, Treatment-Related
  • Neoplasms, Therapy Associated
  • Neoplasms, Therapy Related
  • Neoplasms, Treatment Associated
  • Neoplasms, Treatment Related
  • Second Cancers
  • Second Primary Cancer
  • Second Primary Cancers
  • Therapy Associated Cancer
  • Therapy Associated Neoplasms
  • Therapy Related Cancer
  • Therapy Related Neoplasms
  • Therapy-Associated Cancers
  • Therapy-Associated Neoplasm
  • Therapy-Related Cancers
  • Therapy-Related Neoplasm
  • Treatment Associated Cancer
  • Treatment Associated Neoplasms
  • Treatment Related Cancer
  • Treatment Related Neoplasms
  • Treatment-Associated Cancers
  • Treatment-Associated Neoplasm
  • Treatment-Related Cancers
  • Treatment-Related Neoplasm

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

a 2d or more neopl of same or different histol type at same or different sites: do not confuse with NEOPLASMS, MULTIPLE PRIMARY (see note there); often follows ther (note X refs); IM; coord with each specific histol type (IM) & each precoord organ/neopl term (IM); do not use /compl with specific multiple neopl terms to show multiplicity; Manual 24.4.1.7; differentiate from NEOPLASM METASTASIS (Manual 24.4.1.3+) & NEOPLASM RECURRENCE, LOCAL: Manual 24.4.1.5

MeSH Record

History Note

92

MeSH Record

Previous Indexing

  • Neoplasms, Multiple Primary (1966-1991)

MeSH Hierarchy

Tree Number

  1. C04w.692

AMA Style

References

  1. National Library of Medicine. Second Primary Neoplasms. Medical Subject Headings (MeSH). 2026. Unique ID D016609. http://id.nlm.nih.gov/mesh/2026/D016609
  2. Second Primary Neoplasms. In: Wikidata. https://www.wikidata.org/wiki/Q25402299