Chemicals and Drugs

Saralasin

An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.

Chemical Identity

Chemical Information

Molecular Formula
C42H65N13O10
Molecular Weight
912.0 g/mol
CAS Registry No.
34273-10-4
IUPAC Name
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
InChIKey
PFGWGEPQIUAZME-NXSMLHPHSA-N
SMILES
C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
MeSH Unique ID
D012504
Source
PubChem CID 6324663

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • (Sar(1),Ala(8))ANGII
  • (Sar1,Val5,Ala8)Angiotensin II
  • 1-Sar-8-Ala Angiotensin II
  • 1-Sarcosine-8-Alanine Angiotensin II
  • Angiotensin II, Sar(1)-Ala(8)-
  • Angiotensin II, Sarcosyl(1)-Alanine(8)-
  • Sar-Arg-Val-Tyr-Val-His-Pro-Ala
  • 1 Sar 8 Ala Angiotensin II
  • 1 Sarcosine 8 Alanine Angiotensin II
  • Angiotensin II, 1-Sar-8-Ala
  • Angiotensin II, 1-Sarcosine-8-Alanine
  • Saralasin Acetate
  • Saralasin Acetate, Anhydrous
  • Saralasin Acetate, Hydrated
  • Anhydrous Saralasin Acetate
  • Hydrated Saralasin Acetate

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

1984(1978)

MeSH Record

Previous Indexing

  • Alanine (1974)
  • Angiotensin II (1974)
  • Sarcosine (1974)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.456w.073w.041w.800w
  2. D23.469.050w.050w.050w.700w

MeSH Record

NLM Classification

QU 68

AMA Style

References

  1. National Library of Medicine. Saralasin. Medical Subject Headings (MeSH). 2026. Unique ID D012504. http://id.nlm.nih.gov/mesh/2026/D012504
  2. Saralasin. In: Wikipedia. https://en.wikipedia.org/wiki/Saralasin
  3. Saralasin. In: Wikidata. https://www.wikidata.org/wiki/Q410298
  4. Saralasin. In: PubChem Compound. CID 6324663. https://pubchem.ncbi.nlm.nih.gov/compound/6324663