Chemicals and Drugs

Safrole

A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).

Chemical Identity

Chemical Information

Molecular Formula
C10H10O2
Molecular Weight
162.18 g/mol
CAS Registry No.
94-59-7
IUPAC Name
5-prop-2-enyl-1,3-benzodioxole
InChIKey
ZMQAAUBTXCXRIC-UHFFFAOYSA-N
SMILES
C=CCC1=CC2=C(C=C1)OCO2
MeSH Unique ID
D012451
Source
PubChem CID 5144

MeSH Record

Classification

Related Concepts

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MeSH Record

Synonyms

8 entry terms
  • 4-Allyl-1,2-methylenedioxybenzene
  • Safrol
  • 4 Allyl 1,2 methylenedioxybenzene
  • 4-Allyl-1,2-methylenedioxybenzenes
  • Safroles
  • Safrols
  • Shikimol
  • Shikimols

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

91(75); was see under DIOXOLES 1975-90

MeSH Record

Previous Indexing

  • Allyl Compounds (1972-1974)
  • Dioxoles (1969-1974)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Safrole. Medical Subject Headings (MeSH). 2026. Unique ID D012451. http://id.nlm.nih.gov/mesh/2026/D012451
  2. Safrole. In: Wikipedia. https://en.wikipedia.org/wiki/Safrole
  3. Safrole. In: Wikidata. https://www.wikidata.org/wiki/Q412424
  4. Safrole. In: PubChem Compound. CID 5144. https://pubchem.ncbi.nlm.nih.gov/compound/5144