Chemicals and Drugs

S-Phase Kinase-Associated Proteins

A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

See Also

MeSH Record

Synonyms

19 entry terms
  • S-Phase Kinase Associated Protein
  • Skp Domain Protein
  • Skp Domain Proteins
  • Kinase-Associated Proteins, S-Phase
  • Proteins, S-Phase Kinase-Associated
  • S Phase Kinase Associated Protein
  • S Phase Kinase Associated Proteins
  • SCF(SKP2)
  • Skp1 Protein
  • Skp1 Proteins
  • Skp2 Protein
  • Skp2 Proteins
  • p19 SKP1
  • p19(SKP1) Protein
  • p45 SKP2
  • p45(SKP2)
  • p45(SKP2) Protein
  • SKP1, p19
  • SKP2, p45

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2004; use S-PHASE KINASE ASSOCIATED PROTEINS (NM) 1983-2003; for P19(SKP1)PROTEIN and P45(SKP) PROTEIN use S-PHASE KINASE ASSOCIATED PROTEINS (NM) 1995-2003; for P45(SKP) use UBIQUITIN-PROTEIN LIGASES (NM) 1999-2003

MeSH Record

Previous Indexing

  • Cell Cycle Proteins (1995-2003)
  • Ligases (1983-2003)

MeSH Hierarchy

Tree Number

  1. D12.776w.157w.743

AMA Style

References

  1. National Library of Medicine. S-Phase Kinase-Associated Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D044786. http://id.nlm.nih.gov/mesh/2026/D044786
  2. S-Phase Kinase-Associated Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q58622481