Chemicals and Drugs

Rivaroxaban

A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME.

Chemical Identity

Chemical Information

Molecular Formula
C19H18ClN3O5S
Molecular Weight
435.9 g/mol
CAS Registry No.
366789-02-8
IUPAC Name
5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
InChIKey
KGFYHTZWPPHNLQ-AWEZNQCLSA-N
SMILES
C1COCC(=O)N1C2=CC=C(C=C2)N3C[C@@H](OC3=O)CNC(=O)C4=CC=C(S4)Cl
MeSH Unique ID
D000069552
Source
PubChem CID 9875401

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

5 entry terms
  • 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
  • BAY 59-7939
  • Xarelto
  • BAY 59 7939
  • BAY 597939

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (2005)

MeSH Hierarchy

Tree Numbers

  1. D02w.886w.778.727w
  2. D03w.383.533.640.713w
  3. D03w.383.903.727w

AMA Style

References

  1. National Library of Medicine. Rivaroxaban. Medical Subject Headings (MeSH). 2026. Unique ID D000069552. http://id.nlm.nih.gov/mesh/2026/D000069552
  2. Rivaroxaban. In: Wikipedia. https://en.wikipedia.org/wiki/Rivaroxaban
  3. Rivaroxaban. In: Wikidata. https://www.wikidata.org/wiki/Q420262
  4. Rivaroxaban. In: PubChem Compound. CID 9875401. https://pubchem.ncbi.nlm.nih.gov/compound/9875401