Structured Summary
Abstract
An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. It also inhibits CYTOCHROME P-450 CYP3A.
Chemical Identity
Chemical Information
- Molecular Formula
- C37H48N6O5S2
- Molecular Weight
- 720.9 g/mol
- CAS Registry No.
- 155213-67-5
- IUPAC Name
- 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
- InChIKey
- NCDNCNXCDXHOMX-XGKFQTDJSA-N
- SMILES
- CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
- MeSH Unique ID
- D019438
- Source
- PubChem CID 392622
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- ABT 538
- ABT-538
- Norvir
- ABT538
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
History Note
97; was ABT 538 (NM) 1995-96
MeSH Record
Previous Indexing
- HIV Protease Inhibitors (1995)
- Thiazoles (1996)
- Valine/analogs & derivatives (1996)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Ritonavir. Medical Subject Headings (MeSH). 2026. Unique ID D019438. http://id.nlm.nih.gov/mesh/2026/D019438
- Ritonavir. In: Wikipedia. https://en.wikipedia.org/wiki/Ritonavir
- Ritonavir. In: Wikidata. https://www.wikidata.org/wiki/Q422618
- Ritonavir. In: PubChem Compound. CID 392622. https://pubchem.ncbi.nlm.nih.gov/compound/392622