Chemicals and Drugs

Rifaximin

A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic rifamycin derivative and anti-bacterial agent that is used for the treatment of GASTROENTERITIS caused by ESCHERICHIA COLI INFECTIONS. It may also be used in the treatment of HEPATIC ENCEPHALOPATHY.

Chemical Identity

Chemical Information

Molecular Formula
C43H51N3O11
Molecular Weight
785.9 g/mol
CAS Registry No.
80621-81-4
IUPAC Name
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,36-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22,30-octamethyl-6,23-dioxo-8,37-dioxa-24,27,33-triazahexacyclo[23.10.1.14,7.05,35.026,34.027,32]heptatriaconta-1(35),2,4,9,19,21,25(36),26(34),28,30,32-undecaen-13-yl] acetate
InChIKey
NZCRJKRKKOLAOJ-XRCRFVBUSA-N
SMILES
C[C@H]1/C=C/C=C(\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)/C
MeSH Unique ID
D000078262
Source
PubChem CID 6436173

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin
  • L 105
  • L-105
  • Redactiv
  • Xifaxan
  • L105

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2019 (1983)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.400.811w.850w
  2. D04w.345w.295.750w.850w

AMA Style

References

  1. National Library of Medicine. Rifaximin. Medical Subject Headings (MeSH). 2026. Unique ID D000078262. http://id.nlm.nih.gov/mesh/2026/D000078262
  2. Rifaximin. In: Wikipedia. https://en.wikipedia.org/wiki/Rifaximin
  3. Rifaximin. In: Wikidata. https://www.wikidata.org/wiki/Q416073
  4. Rifaximin. In: PubChem Compound. CID 6436173. https://pubchem.ncbi.nlm.nih.gov/compound/6436173