Chemicals and Drugs

Rifabutin

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients.

Chemical Identity

Chemical Information

Molecular Formula
C46H62N4O11
Molecular Weight
847.0 g/mol
IUPAC Name
[(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23,32-trioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(31),2,4,9,19,21,25,29-octaene-28,4'-piperidine]-13-yl] acetate
InChIKey
ATEBXHFBFRCZMA-VXTBVIBXSA-N
SMILES
C[C@H]1/C=C/C=C(\C(=O)NC2=C3C(=NC4(N3)CCN(CC4)CC(C)C)C5=C(C2=O)C(=C(C6=C5C(=O)[C@](O6)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)/C
MeSH Unique ID
D017828
Source
PubChem CID 6323490

MeSH Record

Classification

Broader headings

Narrower headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Ansamycin
  • Rifabutine
  • Alfacid
  • Ansatipin
  • Ansatipine
  • LM-427
  • Mycobutin
  • LM 427
  • LM427

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

94; was RIFABUTINE (NM) 1981-93

MeSH Record

Previous Indexing

  • Rifamycins (1981-1993)

MeSH Hierarchy

Tree Numbers

  1. D03w.633.400.811w.650w
  2. D04w.345w.295.750w.650w

AMA Style

References

  1. National Library of Medicine. Rifabutin. Medical Subject Headings (MeSH). 2026. Unique ID D017828. http://id.nlm.nih.gov/mesh/2026/D017828
  2. Rifabutin. In: Wikipedia. https://en.wikipedia.org/wiki/Rifabutin
  3. Rifabutin. In: Wikidata. https://www.wikidata.org/wiki/Q1135705
  4. Rifabutin. In: PubChem Compound. CID 6323490. https://pubchem.ncbi.nlm.nih.gov/compound/6323490