Structured Summary
Abstract
N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
15 entry terms
- Polynucleotide Adenosine Glycosidase
- RIP (Ribosome Inactivating Proteins)
- RIP Ribosome Inactivating Proteins
- RNA Glycosylase
- RNA N-Glycosidase
- rRNA N-Glycosylases
- Adenosine Glycosidase, Polynucleotide
- Glycosidase, Polynucleotide Adenosine
- Glycosylase, RNA
- Inactivating Proteins, Ribosome
- N-Glycosidase, RNA
- N-Glycosylases, rRNA
- Proteins, Ribosome Inactivating
- RNA N Glycosidase
- rRNA N Glycosylases
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2008(1988)
MeSH Record
Previous Indexing
- N-Glycosyl Hydrolases (1988-2007)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Ribosome Inactivating Proteins. Medical Subject Headings (MeSH). 2026. Unique ID D054788. http://id.nlm.nih.gov/mesh/2026/D054788
- Ribosome Inactivating Proteins. In: Wikipedia. https://en.wikipedia.org/wiki/Ribosome-inactivating_protein
- Ribosome Inactivating Proteins. In: Wikidata. https://www.wikidata.org/wiki/Q24788543