Diseases

Retinoblastoma

A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)

MeSH Record

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Broader headings

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MeSH Record

Synonyms

31 entry terms
  • Eye Cancer, Retinoblastoma
  • Cancer, Retinoblastoma Eye
  • Cancers, Retinoblastoma Eye
  • Eye Cancers, Retinoblastoma
  • Retinoblastoma Eye Cancer
  • Retinoblastoma Eye Cancers
  • Retinoblastomas
  • Familial Retinoblastoma
  • Glioblastoma, Retinal
  • Glioma, Retinal
  • Hereditary Retinoblastoma
  • Neuroblastoma, Retinal
  • Sporadic Retinoblastoma
  • Familial Retinoblastomas
  • Glioblastomas, Retinal
  • Gliomas, Retinal
  • Hereditary Retinoblastomas
  • Neuroblastomas, Retinal
  • Retinal Glioblastoma
  • Retinal Glioblastomas
  • Retinal Glioma
  • Retinal Gliomas
  • Retinal Neuroblastoma
  • Retinal Neuroblastomas
  • Retinoblastoma, Familial
  • Retinoblastoma, Hereditary
  • Retinoblastoma, Sporadic
  • Retinoblastomas, Familial
  • Retinoblastomas, Hereditary
  • Retinoblastomas, Sporadic
  • Sporadic Retinoblastomas

MeSH Record

Aspects Covered

39 allowable subheadings

Indexed with the subheadings blood, blood supply, cerebrospinal fluid, chemically induced, chemistry, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, secondary, surgery, therapy, ultrastructure, urine, veterinary, virology.

MeSH Record

Indexing Annotation

coordinate IM with RETINAL NEOPLASMS (IM); /genetics: consider also GENES, RETINOBLASTOMA

MeSH Hierarchy

Tree Numbers

  1. C04w.557.465.625w.600.725w
  2. C04w.557.470.670.725w
  3. C04w.557.580.625w.600.725w
  4. C04w.588.364.818.760w
  5. C11w.270.862w
  6. C11w.319.475.760w
  7. C11w.768w.717.760w

MeSH Record

NLM Classification

WW 272

AMA Style

References

  1. National Library of Medicine. Retinoblastoma. Medical Subject Headings (MeSH). 2026. Unique ID D012175. http://id.nlm.nih.gov/mesh/2026/D012175
  2. Retinoblastoma. In: Wikipedia. https://en.wikipedia.org/wiki/Retinoblastoma
  3. Retinoblastoma. In: Wikidata. https://www.wikidata.org/wiki/Q500695