Structured Summary
Abstract
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
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Synonyms
12 entry terms
- Angiotensin-Forming Enzyme
- Angiotensinogenase
- Angiotensin Forming Enzyme
- Big Renin
- Cryorenin
- Inactive Renin
- Pre-Prorenin
- Preprorenin
- Prorenin
- Pre Prorenin
- Renin, Big
- Renin, Inactive
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Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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Indexing Annotation
do not confuse with RENNIN see CHYMOSIN
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History Note
1963; for PRORENIN use RENIN (NM) 1977-2003, for PREPRORENIN use RENIN (NM) 1980-2003
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AMA Style
References
- National Library of Medicine. Renin. Medical Subject Headings (MeSH). 2026. Unique ID D012083. http://id.nlm.nih.gov/mesh/2026/D012083
- Renin. In: Wikipedia. https://en.wikipedia.org/wiki/Renin
- Renin. In: Wikidata. https://www.wikidata.org/wiki/Q258915