Structured Summary
Abstract
A family of cell surface receptors that were originally identified by their structural homology to neurotropic TYROSINE KINASES and referred to as orphan receptors because the associated ligand and signaling pathways were unknown. Evidence for the functionality of these proteins has been established by experiments showing that disruption of the orphan receptor genes results in developmental defects.
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Classification
Broader headings
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Synonyms
15 entry terms
- NTRKR Receptors
- Neurotrophic Tyrosine Kinase, Receptor-related Proteins
- ROR Tyrosine Kinase Receptors
- Receptor Tyrosine Kinase-like Orphan Receptor
- Neurotrophic Tyrosine Kinase, Receptor related Proteins
- Receptor Tyrosine Kinase like Orphan Receptor
- Receptor Tyrosine Kinase like Orphan Receptors
- ROR1 Tyrosine Kinase
- ROR2 Tyrosine Kinase
- Receptor Tyrosine Kinase-like Orphan Receptor 1
- Receptor Tyrosine Kinase-like Orphan Receptor 2
- Kinase, ROR2 Tyrosine
- Receptor Tyrosine Kinase like Orphan Receptor 1
- Receptor Tyrosine Kinase like Orphan Receptor 2
- Tyrosine Kinase, ROR1
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
do not confuse with ORPHAN NUCLEAR RECEPTORS
MeSH Record
History Note
2010
MeSH Record
Previous Indexing
- Protein-Tyrosine Kinase (1983-1993)
- Receptor Protein-Tyrosine Kinases (1994-2009)
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AMA Style
References
- National Library of Medicine. Receptor Tyrosine Kinase-like Orphan Receptors. Medical Subject Headings (MeSH). 2026. Unique ID D057050. http://id.nlm.nih.gov/mesh/2026/D057050
- Receptor Tyrosine Kinase-like Orphan Receptors. In: Wikipedia. https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase-like_orphan_receptor
- Receptor Tyrosine Kinase-like Orphan Receptors. In: Wikidata. https://www.wikidata.org/wiki/Q24782638