Chemicals and Drugs

Ranolazine

An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An acetanilide and piperazine derivative that functions as a SODIUM CHANNEL BLOCKER and prevents the release of enzymes during MYOCARDIAL ISCHEMIA. It is used in the treatment of ANGINA PECTORIS.

Chemical Identity

Chemical Information

Molecular Formula
C24H33N3O4
Molecular Weight
427.5 g/mol
CAS Registry No.
95635-55-5
IUPAC Name
N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide
InChIKey
XKLMZUWKNUAPSZ-UHFFFAOYSA-N
SMILES
CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CC(COC3=CC=CC=C3OC)O
MeSH Unique ID
D000069458
Source
PubChem CID 56959

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

16 entry terms
  • N-(2,6-dimethylphenyl)-4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-1-piperazineacetamide
  • Renolazine
  • RS 43285
  • RS 43285-193
  • RS-43285
  • Ranexa
  • Ranolazine Dihydrochloride
  • Ranolazine HCl
  • Ranolazine Hydrochloride
  • 43285, RS
  • Dihydrochloride, Ranolazine
  • HCl, Ranolazine
  • Hydrochloride, Ranolazine
  • RS 43285 193
  • RS 43285193
  • RS43285

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

2016 (1988)

MeSH Hierarchy

Tree Numbers

  1. D02w.065w.199w.092.850w
  2. D02w.092w.146.113w.092.850w
  3. D03w.383.606w.841w

AMA Style

References

  1. National Library of Medicine. Ranolazine. Medical Subject Headings (MeSH). 2026. Unique ID D000069458. http://id.nlm.nih.gov/mesh/2026/D000069458
  2. Ranolazine. In: Wikipedia. https://en.wikipedia.org/wiki/Ranolazine
  3. Ranolazine. In: Wikidata. https://www.wikidata.org/wiki/Q907104
  4. Ranolazine. In: PubChem Compound. CID 56959. https://pubchem.ncbi.nlm.nih.gov/compound/56959