Phenomena and Processes

RNA 5' Terminal Oligopyrimidine Sequence

A regulatory sequence found in the 5' terminal regions of a variety of RNA species. The sequence starts with a CYTIDINE, which is followed by a stretch of 5 to 15 PYRIMIDINE NUCLEOTIDES. Messenger RNA that contains the 5' Terminal Oligo Pyrimidine tract is often referred to as 5' TOP mRNA. The sequence acts as a translational regulator and has been found in mRNAs for PEPTIDE ELONGATION FACTORS and RIBOSOMAL PROTEINS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A regulatory sequence found in the 5' terminal regions of a variety of RNA species. The sequence starts with a CYTIDINE, which is followed by a stretch of 5 to 15 PYRIMIDINE NUCLEOTIDES. Messenger RNA that contains the 5' Terminal Oligo Pyrimidine tract is often referred to as 5' TOP mRNA. The sequence acts as a translational regulator and has been found in mRNAs for PEPTIDE ELONGATION FACTORS and RIBOSOMAL PROTEINS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

7 entry terms
  • 5' TOP Sequence
  • RNA 5' Terminal Oligopyrimidine Regulatory Sequence
  • 5' TOP Sequences
  • Sequence, 5' TOP
  • Sequences, 5' TOP
  • 5' TOP Messenger RNA
  • 5' TOP mRNA

MeSH Record

Aspects Covered

6 allowable subheadings

Indexed with the subheadings drug effects, ethics, genetics, immunology, physiology, radiation effects.

MeSH Record

History Note

2003

MeSH Hierarchy

Tree Numbers

  1. G02.111.570.080w.689w.687.275
  2. G05.360w.080w.689w.687.275
  3. G05.360w.340w.024.340w.137.785

AMA Style

References

  1. National Library of Medicine. RNA 5' Terminal Oligopyrimidine Sequence. Medical Subject Headings (MeSH). 2026. Unique ID D038641. http://id.nlm.nih.gov/mesh/2026/D038641
  2. RNA 5' Terminal Oligopyrimidine Sequence. In: Wikidata. https://www.wikidata.org/wiki/Q71130461