Chemicals and Drugs

RNA-Binding Protein FUS

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

10 entry terms
  • FUS Protein
  • FUS RNA-Binding Protein
  • Fusion Protein in Myxoid Liposarcoma
  • POMp75 Protein
  • TLS Protein
  • Translocated in Liposarcoma Protein
  • hnRNP P2
  • FUS RNA Binding Protein
  • RNA Binding Protein FUS
  • RNA-Binding Protein, FUS

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for FUS PROTEIN & HNRNP P2 use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1996-2002; for TLS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS (NM) 1993-2002;

MeSH Record

Previous Indexing

  • Ribonucleoproteins (1996-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.157w.725w.500w.313w.905
  2. D12.776w.157w.725w.813.750w.905
  3. D12.776w.624.664.700.915
  4. D12.776w.664w.962w.500w.313w.902
  5. D12.776w.664w.962w.813.750w.902

AMA Style

References

  1. National Library of Medicine. RNA-Binding Protein FUS. Medical Subject Headings (MeSH). 2026. Unique ID D034702. http://id.nlm.nih.gov/mesh/2026/D034702
  2. RNA-Binding Protein FUS. In: Wikidata. https://www.wikidata.org/wiki/Q29564632