Chemicals and Drugs

RNA-Binding Protein EWS

A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A ubiquitous hnRNP protein that contains an RNA RECOGNITION MOTIF and C-terminal ranBP2-type zinc finger. It localizes to the CELL NUCLEUS and CYTOPLASM and is expressed as different isoforms in various tissues, interacting with CALMODULIN and TUMOR SUPPRESSOR PROTEIN P53 to negatively regulate cell growth. Translocations that result in the formation of fusion proteins containing parts of RNA-binding protein EWS are associated with EWING SARCOMA.

MeSH Record

Classification

Broader headings

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MeSH Record

See Also

MeSH Record

Synonyms

11 entry terms
  • EWS Protein
  • EWS Proto-Oncogene Protein
  • EWS RNA Binding Protein 1
  • EWSR1 Protein
  • Ewing Sarcoma Breakpoint Region 1 Protein
  • Ewing Sarcoma Breakpointregion 1 Protein
  • EWS Proto Oncogene Protein
  • EWS, RNA-Binding Protein
  • Protein, EWSR1
  • Proto-Oncogene Protein, EWS
  • RNA Binding Protein EWS

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for EWS PROTEIN use HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS 1995-2002

MeSH Record

Previous Indexing

  • Ribonucleoproteins (1995-2002)

MeSH Hierarchy

Tree Numbers

  1. D12.644w.360.650w
  2. D12.776w.157w.142w.750w
  3. D12.776w.157w.725w.500w.313w.900w
  4. D12.776w.157w.725w.813.750w.900w
  5. D12.776w.476.650w
  6. D12.776w.624.664.700.913w
  7. D12.776w.664w.962w.500w.313w.900w
  8. D12.776w.664w.962w.813.750w.900w

AMA Style

References

  1. National Library of Medicine. RNA-Binding Protein EWS. Medical Subject Headings (MeSH). 2026. Unique ID D034802. http://id.nlm.nih.gov/mesh/2026/D034802
  2. RNA-Binding Protein EWS. In: Wikipedia. https://en.wikipedia.org/wiki/RNA-binding_protein_EWS
  3. RNA-Binding Protein EWS. In: Wikidata. https://www.wikidata.org/wiki/Q17917676