Chemicals and Drugs

Pyruvate Kinase

ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

ATP:pyruvate 2-O-phosphotransferase. A phosphotransferase that catalyzes reversibly the phosphorylation of pyruvate to phosphoenolpyruvate in the presence of ATP. It has four isozymes (L, R, M1, and M2). Deficiency of the enzyme results in hemolytic anemia. EC 2.7.1.40.

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Classification

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Synonyms

16 entry terms
  • L-Type Pyruvate Kinase
  • M-Type Pyruvate Kinase
  • M1-Type Pyruvate Kinase
  • M2-Type Pyruvate Kinase
  • Pyruvate Kinase L
  • R-Type Pyruvate Kinase
  • L Type Pyruvate Kinase
  • M Type Pyruvate Kinase
  • M1 Type Pyruvate Kinase
  • M2 Type Pyruvate Kinase
  • Pyruvate Kinase, L-Type
  • Pyruvate Kinase, M-Type
  • Pyruvate Kinase, M1-Type
  • Pyruvate Kinase, M2-Type
  • Pyruvate Kinase, R-Type
  • R Type Pyruvate Kinase

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

do not coord L-, R-, M-, M1- or M2-type pyruvate kinase with ISOENZYMES

MeSH Record

History Note

65

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AMA Style

References

  1. National Library of Medicine. Pyruvate Kinase. Medical Subject Headings (MeSH). 2026. Unique ID D011770. http://id.nlm.nih.gov/mesh/2026/D011770
  2. Pyruvate Kinase. In: Wikipedia. https://en.wikipedia.org/wiki/Pyruvate_kinase
  3. Pyruvate Kinase. In: Wikidata. https://www.wikidata.org/wiki/Q900970