Structured Summary
Abstract
Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
12 entry terms
- 2-Oxo Acid Carboxy-Lyase
- Pyruvic Decarboxylase
- alpha-Carboxylase
- alpha-Ketoacid Carboxylase
- 2 Oxo Acid Carboxy Lyase
- Acid Carboxy-Lyase, 2-Oxo
- Carboxy-Lyase, 2-Oxo Acid
- Carboxylase, alpha-Ketoacid
- Decarboxylase, Pyruvate
- Decarboxylase, Pyruvic
- alpha Carboxylase
- alpha Ketoacid Carboxylase
MeSH Record
Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
91(75); was see under CARBOXY-LYASES 1975-90
MeSH Record
Previous Indexing
- Carboxy-Lyases (1973-1974)
- Pyruvates (1973-1974)
MeSH Hierarchy
Tree Number
AMA Style
References
- National Library of Medicine. Pyruvate Decarboxylase. Medical Subject Headings (MeSH). 2026. Unique ID D011767. http://id.nlm.nih.gov/mesh/2026/D011767
- Pyruvate Decarboxylase. In: Wikipedia. https://en.wikipedia.org/wiki/Pyruvate_decarboxylase
- Pyruvate Decarboxylase. In: Wikidata. https://www.wikidata.org/wiki/Q268414