Structured Summary
Abstract
A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
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Synonyms
7 entry terms
- Pyrrolizidine Alkaloid
- Alkaloid, Pyrrolizidine
- Alkaloids, Pyrrolizidine
- Senecio Alkaloid
- Senecio Alkaloids
- Alkaloid, Senecio
- Alkaloids, Senecio
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Aspects Covered
24 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
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History Note
73(71)
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Previous Indexing
- Alkaloids (1966-1970)
- Heterocyclic Compounds (1966-1970)
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AMA Style
References
- National Library of Medicine. Pyrrolizidine Alkaloids. Medical Subject Headings (MeSH). 2026. Unique ID D011763. http://id.nlm.nih.gov/mesh/2026/D011763
- Pyrrolizidine Alkaloids. In: Wikipedia. https://en.wikipedia.org/wiki/Pyrrolizidine_alkaloid
- Pyrrolizidine Alkaloids. In: Wikidata. https://www.wikidata.org/wiki/Q75005794