Chemicals and Drugs

Pyrroline Carboxylate Reductases

A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A group of enzymes that catalyze the reduction of 1-pyrroline carboxylate to proline in the presence of NAD(P)H. Includes both the 2-oxidoreductase (EC 1.5.1.1) and the 5-oxidoreductase (EC 1.5.1.2). The former also reduces 1-piperidine-2-carboxylate to pipecolate and the latter also reduces 1-pyrroline-3-hydroxy-5-carboxylate to hydroxyproline.

MeSH Record

Classification

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

2 entry terms
  • Carboxylate Reductases, Pyrroline
  • Reductases, Pyrroline Carboxylate

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

91(77); was see under AMINE OXIDOREDUCTASES 1977-90

MeSH Record

Previous Indexing

  • Amine Oxidoreductases (1975-1976)
  • Oxidoreductases (1966-1974)

MeSH Hierarchy

Tree Number

AMA Style

References

  1. National Library of Medicine. Pyrroline Carboxylate Reductases. Medical Subject Headings (MeSH). 2026. Unique ID D011762. http://id.nlm.nih.gov/mesh/2026/D011762
  2. Pyrroline Carboxylate Reductases. In: Wikidata. https://www.wikidata.org/wiki/Q78193928