Structured Summary
Abstract
A thiamine antagonist due to its inhibition of thiamine pyrophosphorylation. It is used to produce thiamine deficiency.
Chemical Identity
Chemical Information
- Molecular Formula
- C14H19BrN4O
- Molecular Weight
- 339.23 g/mol
- CAS Registry No.
- 616-92-2
- IUPAC Name
- 2-[1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium-3-yl]ethanol bromide
- InChIKey
- GUWSQVZFXHIGLN-UHFFFAOYSA-M
- SMILES
- CC1=C(C=CC=[N+]1CC2=CN=C(N=C2N)C)CCO.[Br-]
- MeSH Unique ID
- D011745
- Source
- PubChem CID 5460202
MeSH Record
Classification
Broader headings
Related Concepts
Knowledge Graph
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
4 entry terms
- Heterovitamin B 1
- Neopyrithiamine
- 1, Heterovitamin B
- B 1, Heterovitamin
MeSH Record
Aspects Covered
25 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.
MeSH Record
Indexing Annotation
a thiamine antag
MeSH Record
History Note
91(77); was see under PYRIDINIUM COMPOUNDS 1977-90
MeSH Record
Previous Indexing
- Pyridinium Compounds (1974-1976)
- Pyrimidines (1974-1976)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Pyrithiamine. Medical Subject Headings (MeSH). 2026. Unique ID D011745. http://id.nlm.nih.gov/mesh/2026/D011745
- Pyrithiamine. In: Wikidata. https://www.wikidata.org/wiki/Q27098236
- Pyrithiamine. In: PubChem Compound. CID 5460202. https://pubchem.ncbi.nlm.nih.gov/compound/5460202