Structured Summary
Abstract
A protein interaction domain of the death domain superfamily. It is characterized by a 6-helix bundle similar to those that occur in DEATH DOMAIN RECEPTORS. Pyrin domains are present in a variety of proteins, especially those that function in INFLAMMASOMES; AUTOPHAGY; and APOPTOSIS. They form homodimers or heterodimers with death domain proteins to facilitate the assembly of signaling complexes.
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Synonyms
10 entry terms
- DAPIN Domain
- PAAD-DAPIN-PYRIN Domain
- PADD Domain
- PYD Domain
- DAPIN Domains
- PAAD DAPIN PYRIN Domain
- PAAD-DAPIN-PYRIN Domains
- PADD Domains
- PYD Domains
- Pyrin Domains
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Aspects Covered
5 allowable subheadings
Indexed with the subheadings drug effects, genetics, immunology, physiology, radiation effects.
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History Note
2017
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Previous Indexing
- Cytoskeletal Proteins (2001-2016)
- Protein Structure, Tertiary (2001-2016)
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AMA Style
References
- National Library of Medicine. Pyrin Domain. Medical Subject Headings (MeSH). 2026. Unique ID D000071196. http://id.nlm.nih.gov/mesh/2026/D000071196
- Pyrin Domain. In: Wikipedia. https://en.wikipedia.org/wiki/Pyrin_domain
- Pyrin Domain. In: Wikidata. https://www.wikidata.org/wiki/Q24725912