Chemicals and Drugs

Pyrimidine Dimers

Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.

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Classification

Broader headings

Related Concepts

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See Also

MeSH Record

Synonyms

21 entry terms
  • Cyclobutane Pyrimidine Dimer
  • Cyclobutane-Pyrimidine Dimer
  • Cyclobutane-Pyrimidine Dimers
  • Pyrimidine Dimer
  • Cyclobutane Pyrimidine Dimers
  • Pyrimidine Dimer, Cyclobutane
  • Pyrimidine Dimers, Cyclobutane
  • Cytosine-Thymine Dimer
  • Cytosine-Thymine Dimers
  • Thymine Dimer
  • Thymine Dimers
  • Thymine-Cyclobutane Dimer
  • Thymine-Thymine Cyclobutane Dimer
  • Cyclobutane Dimer, Thymine-Thymine
  • Cyclobutane Dimers, Thymine-Thymine
  • Cytosine Thymine Dimer
  • Cytosine Thymine Dimers
  • Thymine Cyclobutane Dimer
  • Thymine Thymine Cyclobutane Dimer
  • Thymine-Cyclobutane Dimers
  • Thymine-Thymine Cyclobutane Dimers

MeSH Record

Aspects Covered

28 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

77

MeSH Record

Previous Indexing

  • Pyrimidine Nucleotides (1974-1976)
  • Thymine Nucleotides (1972-1976)

MeSH Hierarchy

Tree Numbers

  1. D03w.383.742.686.600w
  2. D13.695w.578w.424w.600w
  3. D13.695w.740.600w
  4. G05.200w.615w

AMA Style

References

  1. National Library of Medicine. Pyrimidine Dimers. Medical Subject Headings (MeSH). 2026. Unique ID D011740. http://id.nlm.nih.gov/mesh/2026/D011740
  2. Pyrimidine Dimers. In: Wikipedia. https://en.wikipedia.org/wiki/Pyrimidine_dimer
  3. Pyrimidine Dimers. In: Wikidata. https://www.wikidata.org/wiki/Q1018722