Chemicals and Drugs

Pulmonary Surfactant-Associated Protein C

A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.

MeSH Record

Classification

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

9 entry terms
  • Pulmonary Surfactant Protein C
  • Pulmonary Surfactant-Associated Protein SP-C
  • SP-C protein
  • Surfactant Polypeptide SP-C
  • Pulmonary Surfactant Associated Protein C
  • Pulmonary Surfactant Associated Protein SP C
  • SP C protein
  • SP-C, Surfactant Polypeptide
  • Surfactant Polypeptide SP C

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; use PULMONARY SURFACTANT-ASSOCIATED PROTEIN C (NM) 1990-2002

MeSH Record

Previous Indexing

  • Proteolipids (1990-2002)
  • Pulmonary Surfactants (1990-2002)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Pulmonary Surfactant-Associated Protein C. Medical Subject Headings (MeSH). 2026. Unique ID D037721. http://id.nlm.nih.gov/mesh/2026/D037721
  2. Pulmonary Surfactant-Associated Protein C. In: Wikidata. https://www.wikidata.org/wiki/Q24739784