Chemicals and Drugs

Proto-Oncogene Proteins p21(ras)

Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC 3.6.1.47.

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Synonyms

43 entry terms
  • Proto-Oncogene Protein p21(ras)
  • Proto-Oncogene Protein ras
  • Proto-Oncogene Proteins c-ras
  • c-ras Proteins
  • p21 c-ras
  • p21(c-ras)
  • p21(ras)
  • ras Proto-Oncogene Product p21
  • ras Proto-Oncogene Protein p21
  • Proteins c-ras, Proto-Oncogene
  • Proto Oncogene Protein ras
  • Proto Oncogene Proteins c ras
  • c ras Proteins
  • c-ras, Proto-Oncogene Proteins
  • c-ras, p21
  • p21 c ras
  • ras Proto Oncogene Product p21
  • ras Proto Oncogene Protein p21
  • ras, Proto-Oncogene Protein
  • Proto-Oncogene Protein p21(c-Ha-ras)
  • Proto-Oncogene Protein p21(c-Ki-ras)
  • Proto-Oncogene Protein p21(c-N-ras)
  • c-Ha-ras p21
  • c-Ki-ras p21
  • p21 c-H-ras
  • p21 c-Ha-ras
  • p21 c-K-ras
  • p21 c-Ki-ras
  • p21(N-ras)
  • p21(c-Ha-ras)
  • p21(c-Ki-ras)
  • c Ha ras p21
  • c Ki ras p21
  • c-H-ras, p21
  • c-Ha-ras, p21
  • c-K-ras, p21
  • c-Ki-ras, p21
  • p21 c H ras
  • p21 c Ha ras
  • p21 c K ras
  • p21 c Ki ras
  • p21, c-Ha-ras
  • p21, c-Ki-ras

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1991)

MeSH Record

Previous Indexing

  • Neoplasm Proteins (1983-1986)
  • Proto-Oncogene Proteins (1987-1990)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.040w.330.300.400.500w.600
  2. D12.776w.157w.325.515.500w.600
  3. D12.776w.476.338.400.500w.600
  4. D12.776w.624.664.700.200

AMA Style

References

  1. National Library of Medicine. Proto-Oncogene Proteins p21(ras). Medical Subject Headings (MeSH). 2026. Unique ID D016283. http://id.nlm.nih.gov/mesh/2026/D016283
  2. Proto-Oncogene Proteins p21(ras). In: Wikidata. https://www.wikidata.org/wiki/Q78316242