Chemicals and Drugs

Proto-Oncogene Proteins c-met

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia.

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

17 entry terms
  • HGF Receptor
  • Hepatocyte Growth Factor Receptor
  • MET Proto-Oncogene, Receptor Tyrosine Kinase
  • MET Receptor Tyrosine Kinase
  • Receptor, HGF
  • Receptor, Hepatocyte Growth Factor
  • Receptor, Scatter Factor
  • Scatter Factor Receptor
  • c-Met Receptor Tyrosine Kinase
  • c-met Proteins
  • met Proto-Oncogene Proteins
  • MET Proto Oncogene, Receptor Tyrosine Kinase
  • Proto Oncogene Proteins c met
  • Proto-Oncogene Proteins, met
  • c Met Receptor Tyrosine Kinase
  • c met Proteins
  • met Proto Oncogene Proteins

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006, 1998-1999

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.075w
  2. D12.776w.476.568w.400w.075w
  3. D12.776w.543w.750w.630w.186w
  4. D12.776w.543w.750w.750w.400w.100w
  5. D12.776w.624.664.700.186w

AMA Style

References

  1. National Library of Medicine. Proto-Oncogene Proteins c-met. Medical Subject Headings (MeSH). 2026. Unique ID D019859. http://id.nlm.nih.gov/mesh/2026/D019859
  2. Proto-Oncogene Proteins c-met. In: Wikipedia. https://en.wikipedia.org/wiki/Hepatocyte_growth_factor_receptor
  3. Proto-Oncogene Proteins c-met. In: Wikidata. https://www.wikidata.org/wiki/Q5005897