Chemicals and Drugs

Proto-Oncogene Proteins c-kit

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

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Synonyms

26 entry terms
  • Antigens, CD117
  • CD117 Antigen
  • CD117 Antigens
  • Proto-Oncogene Protein c-kit
  • Proto-Oncogene Protein kit
  • Receptor, Stem Cell Factor
  • SCF Receptor
  • Stem Cell Factor Receptor
  • c-kit Protein
  • c-kit Receptor
  • kit Proto-Oncogene Protein
  • p145 c-kit
  • p145(c-kit)
  • p145c-kit
  • Proto Oncogene Protein c kit
  • Proto Oncogene Protein kit
  • Proto Oncogene Proteins c kit
  • Proto-Oncogene Protein, kit
  • c kit Protein
  • c kit Receptor
  • c-kit, Proto-Oncogene Protein
  • c-kit, Proto-Oncogene Proteins
  • c-kit, p145
  • kit Proto Oncogene Protein
  • p145 c kit
  • p145c kit

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2000(1996); use PROTO-ONCOGENE PROTEIN c-KIT (NM) 1989-1995

MeSH Record

Previous Indexing

  • Proto-Oncogene Proteins (1989-1995)
  • Receptor Protein-Tyrosine Kinase (1994-1995)
  • Receptors, Colony-Stimulating Factor (1991-1995)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.725w.400w.050w
  2. D12.776w.476.568w.400w.050w
  3. D12.776w.543w.750w.630w.124w
  4. D12.776w.543w.750w.705w.852w.150.100w
  5. D12.776w.543w.750w.750w.400w.200.170w
  6. D12.776w.624.664.700.183w

AMA Style

References

  1. National Library of Medicine. Proto-Oncogene Proteins c-kit. Medical Subject Headings (MeSH). 2026. Unique ID D019009. http://id.nlm.nih.gov/mesh/2026/D019009
  2. Proto-Oncogene Proteins c-kit. In: Wikipedia. https://en.wikipedia.org/wiki/KIT_gene
  3. Proto-Oncogene Proteins c-kit. In: Wikidata. https://www.wikidata.org/wiki/Q909409