Chemicals and Drugs

Proto-Oncogene Proteins c-jun

Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.

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Synonyms

20 entry terms
  • Proto-Oncogene Products c-jun
  • Proto-Oncogene Proteins jun
  • c-fos-Associated Protein p39
  • c-jun Proteins
  • fos-Associated Protein p39
  • jun Proto-Oncogene Product p39
  • jun Proto-Oncogene Proteins
  • p39 c-jun
  • p39(c-jun)
  • Proto Oncogene Products c jun
  • Proto Oncogene Proteins c jun
  • Proto Oncogene Proteins jun
  • c fos Associated Protein p39
  • c jun Proteins
  • fos Associated Protein p39
  • jun Proto Oncogene Product p39
  • jun Proto Oncogene Proteins
  • p39 c jun
  • jun B Proteins
  • jun D Proteins

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Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

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History Note

92; was PROTO-ONCOGENE PROTEIN JUN (NM) 1988-91

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Previous Indexing

  • DNA-Binding Proteins (1987-1991)
  • Proto-Oncogene Proteins (1987-1991)
  • Transcription Factors (1987-1991)

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Tree Numbers

  1. D12.776w.260w.108.820w
  2. D12.776w.624.664.700.182w
  3. D12.776w.660w.763w
  4. D12.776w.930w.127.820w

AMA Style

References

  1. National Library of Medicine. Proto-Oncogene Proteins c-jun. Medical Subject Headings (MeSH). 2026. Unique ID D016755. http://id.nlm.nih.gov/mesh/2026/D016755
  2. Proto-Oncogene Proteins c-jun. In: Wikipedia. https://en.wikipedia.org/wiki/Transcription_factor_Jun
  3. Proto-Oncogene Proteins c-jun. In: Wikidata. https://www.wikidata.org/wiki/Q5005943