Structured Summary
Abstract
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
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Synonyms
16 entry terms
- Breakpoint Cluster Region Protein
- Proto-Oncogene Protein bcr
- Proto-Oncogene Protein c-bcr
- bcr Proto-Oncogene Proteins
- c-bcr Proteins
- c-bcr Proto-Oncogene Proteins
- Proto Oncogene Protein bcr
- Proto Oncogene Protein c bcr
- Proto Oncogene Proteins c bcr
- Proto-Oncogene Proteins, bcr
- Proto-Oncogene Proteins, c-bcr
- bcr Proto Oncogene Proteins
- c bcr Proteins
- c bcr Proto Oncogene Proteins
- c-bcr, Proto-Oncogene Protein
- c-bcr, Proto-Oncogene Proteins
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Aspects Covered
29 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2006(1988)
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References
- National Library of Medicine. Proto-Oncogene Proteins c-bcr. Medical Subject Headings (MeSH). 2026. Unique ID D051562. http://id.nlm.nih.gov/mesh/2026/D051562
- Proto-Oncogene Proteins c-bcr. In: Wikipedia. https://en.wikipedia.org/wiki/BCR_(gene)
- Proto-Oncogene Proteins c-bcr. In: Wikidata. https://www.wikidata.org/wiki/Q903924