Structured Summary
Abstract
Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.
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Synonyms
16 entry terms
- PROTAC Proteolysis Targeting Chimera
- PROTACs
- Proteolysis Targeting Chimeras
- Chimeras, Proteolysis Targeting
- Targeting Chimeras, Proteolysis
- Cereblon-Based Small-Molecule Compounds
- IAP-Based PROTACs
- MDM2 Protein-Based PROTACs
- Phospho-Dependent PROTACs
- PhosphoPROTACs
- VHL-Based PROTACs
- Cereblon Based Small Molecule Compounds
- IAP Based PROTACs
- MDM2 Protein Based PROTACs
- Phospho Dependent PROTACs
- VHL Based PROTACs
MeSH Record
Aspects Covered
18 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, chemical synthesis, chemistry, classification, economics, history, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity.
MeSH Record
History Note
2023
MeSH Record
Previous Indexing
- Proteolysis (2015-2022)
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AMA Style
References
- National Library of Medicine. Proteolysis Targeting Chimera. Medical Subject Headings (MeSH). 2026. Unique ID D000094243. http://id.nlm.nih.gov/mesh/2026/D000094243
- Proteolysis Targeting Chimera. In: Wikipedia. https://en.wikipedia.org/wiki/Proteolysis_targeting_chimera
- Proteolysis Targeting Chimera. In: Wikidata. https://www.wikidata.org/wiki/Q25324636