Diseases

Protein S Deficiency

An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • Deficiency, Protein S
  • Hereditary Thrombophilia Due To Protein S Deficiency
  • Deficiencies, Protein S
  • Protein S Deficiencies

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

95

MeSH Record

Previous Indexing

  • Glycoproteins/deficiency (1984-1992)
  • Protein S/deficiency (1993-1994)

MeSH Hierarchy

Tree Numbers

  1. C15.378w.100w.800w
  2. C15.378w.147.890w
  3. C15.378w.925w.800w

AMA Style

References

  1. National Library of Medicine. Protein S Deficiency. Medical Subject Headings (MeSH). 2026. Unique ID D018455. http://id.nlm.nih.gov/mesh/2026/D018455
  2. Protein S Deficiency. In: Wikipedia. https://en.wikipedia.org/wiki/Protein_S_deficiency
  3. Protein S Deficiency. In: Wikidata. https://www.wikidata.org/wiki/Q3043153