Chemicals and Drugs

Protein S

The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.

MeSH Record

Classification

Related Concepts

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Drug Class

Pharmacological Action

MeSH Record

Synonyms

6 entry terms
  • Cofactor Protein S
  • Protein S, Vitamin K-Dependent
  • Vitamin K-Dependent Protein S
  • Protein S, Cofactor
  • Protein S, Vitamin K Dependent
  • Vitamin K Dependent Protein S

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

Indexing Annotation

a blood protein; an anticoagulant

MeSH Record

History Note

93; was PROTEIN S, VITAMIN K-DEPENDENT (NM) 1979-92

MeSH Record

Previous Indexing

  • Glycoproteins (1980-1992)
  • Vitamin K (1979-1980)

MeSH Hierarchy

Tree Numbers

AMA Style

References

  1. National Library of Medicine. Protein S. Medical Subject Headings (MeSH). 2026. Unique ID D017293. http://id.nlm.nih.gov/mesh/2026/D017293
  2. Protein S. In: Wikidata. https://www.wikidata.org/wiki/Q24783323