Chemicals and Drugs

Protein Phosphatase 2

A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

27 entry terms
  • Protein Phosphatase-2A
  • Protein Phosphatase 2A
  • PPP2CA Phosphatase
  • PPP2CB Phosphatase
  • Protein Phosphatase 2, Catalytic Subunit
  • Protein Phosphatase 2, Catalytic Subunit, alpha Isoform
  • Protein Phosphatase 2, Catalytic Subunit, beta Isoform
  • Protein Phosphatase 2, Regulatory Subunit
  • Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform
  • Protein Phosphatase 2, Regulatory Subunit A, beta Isoform
  • Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform
  • Protein Phosphatase 2, Regulatory Subunit B, beta Isoform
  • Protein Phosphatase 2, Regulatory Subunit B, delta Isoform
  • Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform
  • Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform
  • Protein Phosphatase 2A, Catalytic Subunit, beta Isoform
  • Protein Phosphatase 2A, Regulatory Subunit A, alpha Isoform
  • Protein Phosphatase 2A, Regulatory Subunit A, beta Isoform
  • Protein Phosphatase 2A, Regulatory Subunit B, alpha Isoform
  • Protein Phosphatase 2A, Regulatory Subunit B, beta Isoform
  • Protein Phosphatase 2A, Regulatory Subunit B, delta Isoform
  • Protein Phosphatase 2A, Regulatory Subunit B, gamma Isoform
  • Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform
  • Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform
  • Phosphatase, PPP2CA
  • Phosphatase, PPP2CB
  • Serine Threonine Protein Phosphatase 2A Catalytic Subunit alpha Isoform

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1985); for PROTEIN PHOSPHATASE-2A use PHOSPHOPROTEIN PHOSPHATASE 1 1985-2007

MeSH Record

Previous Indexing

  • Phosphoprotein Phosphatases (1985-2007)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.625w.706w
  2. D12.776w.476.559w.706w

AMA Style

References

  1. National Library of Medicine. Protein Phosphatase 2. Medical Subject Headings (MeSH). 2026. Unique ID D054648. http://id.nlm.nih.gov/mesh/2026/D054648
  2. Protein Phosphatase 2. In: Wikipedia. https://en.wikipedia.org/wiki/Protein_phosphatase_2
  3. Protein Phosphatase 2. In: Wikidata. https://www.wikidata.org/wiki/Q6593007