Chemicals and Drugs

Protein Phosphatase 1

A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

29 entry terms
  • PP1c Enzyme
  • Protein Phosphatase-1
  • Type 1 Serine Threonine Protein Phosphatase
  • Phosphoprotein Phosphatase-1 delta
  • Phosphoprotein Phosphatase-1 gamma 1
  • Protein Phosphatase 1, Catalytic Subunit
  • Protein Phosphatase 1, Catalytic Subunit, alpha Isoform
  • Protein Phosphatase 1, Catalytic Subunit, beta Isoform
  • Protein Phosphatase 1, Catalytic Subunit, delta Isoform
  • Protein Phosphatase 1, Catalytic Subunit, gamma Isoform
  • Protein Phosphatase 1, Catalytic Subunit, gamma1 Isoform
  • Protein Phosphatase 1, Catalytic Subunit, gamma2 Isoform
  • Protein Phosphatase 1, Inhibitory Subunit
  • Protein Phosphatase 1, Regulatory Subunit
  • Protein Phosphatase 1C
  • Protein Phosphatase 1C gamma
  • Protein Phosphatase 1gamma
  • Protein Phosphatase-1 alpha
  • Protein Phosphatase-1 gamma 2
  • Protein Phosphatase-1G
  • Protein Serine-Threonine Phosphatase 1 beta
  • Protein-Serine-Threonine Phosphatase 1 beta
  • Phosphatase-1 delta, Phosphoprotein
  • Phosphoprotein Phosphatase 1 delta
  • Phosphoprotein Phosphatase 1 gamma 1
  • Protein Phosphatase 1 alpha
  • Protein Phosphatase 1 gamma 2
  • Protein Phosphatase 1G
  • Protein Serine Threonine Phosphatase 1 beta

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2008(1983); for PROTEIN PHOSPHATASE-1 use PHOSPHOPROTEIN PHOSPHATASES 1984-2007

MeSH Record

Previous Indexing

  • Phosphoprotein Phosphatases (1984-2007)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.277w.352w.650w.625w.687w
  2. D12.776w.476.559w.687w

AMA Style

References

  1. National Library of Medicine. Protein Phosphatase 1. Medical Subject Headings (MeSH). 2026. Unique ID D054645. http://id.nlm.nih.gov/mesh/2026/D054645
  2. Protein Phosphatase 1. In: Wikipedia. https://en.wikipedia.org/wiki/Protein_phosphatase_1
  3. Protein Phosphatase 1. In: Wikidata. https://www.wikidata.org/wiki/Q7251492