Chemicals and Drugs

Protein Kinase C-theta

A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

MeSH Record

Classification

Broader headings

Related Concepts

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MeSH Record

Synonyms

5 entry terms
  • PKC-theta
  • PRKCQ
  • Protein Kinase C theta
  • Protein Kinase C, theta
  • PKC theta

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Isoenzymes (1992-2017)
  • Protein Kinase C (1992-2017)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.725w.075
  2. D12.776w.476.563w.725w.075

AMA Style

References

  1. National Library of Medicine. Protein Kinase C-theta. Medical Subject Headings (MeSH). 2026. Unique ID D000074121. http://id.nlm.nih.gov/mesh/2026/D000074121
  2. Protein Kinase C-theta. In: Wikidata. https://www.wikidata.org/wiki/Q24772206