Chemicals and Drugs

Protein Kinase C-alpha

A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

5 entry terms
  • PKC-alpha Serine-Threonine Kinase
  • Protein Kinase C alpha
  • Protein Kinase C(alpha)
  • PKC alpha Serine Threonine Kinase
  • Serine-Threonine Kinase, PKC-alpha

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2006(1999)

MeSH Hierarchy

Tree Numbers

  1. D08.811w.913w.696w.620.682w.700w.725w.100
  2. D12.776w.476.563w.725w.100

AMA Style

References

  1. National Library of Medicine. Protein Kinase C-alpha. Medical Subject Headings (MeSH). 2026. Unique ID D051571. http://id.nlm.nih.gov/mesh/2026/D051571
  2. Protein Kinase C-alpha. In: Wikidata. https://www.wikidata.org/wiki/Q7119501