Structured Summary
Abstract
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
MeSH Record
Classification
Broader headings
Related Concepts
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
5 entry terms
- Protamine
- Protamine Chloride
- Protamine Sulfate
- Chloride, Protamine
- Sulfate, Protamine
MeSH Record
Aspects Covered
27 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
Indexing Annotation
heparin antag
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Protamines. Medical Subject Headings (MeSH). 2026. Unique ID D011479. http://id.nlm.nih.gov/mesh/2026/D011479
- Protamines. In: Wikipedia. https://en.wikipedia.org/wiki/Protamine
- Protamines. In: Wikidata. https://www.wikidata.org/wiki/Q5449573