Chemicals and Drugs

Prostaglandin D2

The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.

Chemical Identity

Chemical Information

Molecular Formula
C20H32O5
Molecular Weight
352.5 g/mol
CAS Registry No.
41598-07-6
IUPAC Name
(Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid
InChIKey
BHMBVRSPMRCCGG-OUTUXVNYSA-N
SMILES
CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@H](CC1=O)O)C/C=C\CCCC(=O)O)O
MeSH Unique ID
D015230
Source
PubChem CID 448457

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

9 entry terms
  • 11-Dehydroprostaglandin F2 alpha
  • 11-Dehydroprostaglandin F2alpha
  • PGD2
  • 11 Dehydroprostaglandin F2 alpha
  • 11 Dehydroprostaglandin F2alpha
  • D2, Prostaglandin
  • F2 alpha, 11-Dehydroprostaglandin
  • F2alpha, 11-Dehydroprostaglandin
  • alpha, 11-Dehydroprostaglandin F2

MeSH Record

Aspects Covered

29 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

History Note

89

MeSH Record

Previous Indexing

  • Prostaglandins (1966-1977)
  • Prostaglandins D (1978-1988)

MeSH Hierarchy

Tree Numbers

  1. D10w.251w.355w.255w.550w.200.200w
  2. D23.469.050w.175w.725w.200.200w

AMA Style

References

  1. National Library of Medicine. Prostaglandin D2. Medical Subject Headings (MeSH). 2026. Unique ID D015230. http://id.nlm.nih.gov/mesh/2026/D015230
  2. Prostaglandin D2. In: Wikipedia. https://en.wikipedia.org/wiki/Prostaglandin_D2
  3. Prostaglandin D2. In: Wikidata. https://www.wikidata.org/wiki/Q419750
  4. Prostaglandin D2. In: PubChem Compound. CID 448457. https://pubchem.ncbi.nlm.nih.gov/compound/448457