Structured Summary
Abstract
A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS.
MeSH Record
Classification
Broader headings
Related Concepts
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MeSH Record
Synonyms
7 entry terms
- NARC-1 Protein
- Neural Apoptosis-Regulated Convertase 1
- Proprotein Convertase, Subtilisin-Kexin Type 9
- Convertase 9, Proprotein
- NARC 1 Protein
- Neural Apoptosis Regulated Convertase 1
- Proprotein Convertase, Subtilisin Kexin Type 9
MeSH Record
Aspects Covered
28 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, analysis, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
MeSH Record
History Note
2017
MeSH Record
Previous Indexing
- Proprotein Convertases (2003-2016)
- Serine Endopeptidases (2003-2016)
MeSH Hierarchy
Tree Numbers
AMA Style
References
- National Library of Medicine. Proprotein Convertase 9. Medical Subject Headings (MeSH). 2026. Unique ID D000071449. http://id.nlm.nih.gov/mesh/2026/D000071449
- Proprotein Convertase 9. In: Wikipedia. https://en.wikipedia.org/wiki/PCSK9
- Proprotein Convertase 9. In: Wikidata. https://www.wikidata.org/wiki/Q21130010