Structured Summary
Abstract
A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.
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Broader headings
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Drug Class
Pharmacological Action
MeSH Record
Synonyms
2 entry terms
- Complement Factor P
- Factor P, Complement
MeSH Record
Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, biosynthesis, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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MeSH Record
NLM Classification
QW 680
AMA Style
References
- National Library of Medicine. Properdin. Medical Subject Headings (MeSH). 2026. Unique ID D011414. http://id.nlm.nih.gov/mesh/2026/D011414
- Properdin. In: Wikidata. https://www.wikidata.org/wiki/Q22677535