Chemicals and Drugs

Promyelocytic Leukemia Zinc Finger Protein

A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.

MeSH Record

Classification

Broader headings

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MeSH Record

Synonyms

4 entry terms
  • PLZF Protein
  • Promyelocytic Leukaemia Zinc Finger Protein
  • ZBTB16 Protein
  • Zinc Finger and BTB Domain Containing 16 Protein

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2018

MeSH Record

Previous Indexing

  • Kruppel-Like Transcription Factors (1995-2017)

MeSH Hierarchy

Tree Numbers

  1. D12.776w.260w.522w.625
  2. D12.776w.930w.375w.625

AMA Style

References

  1. National Library of Medicine. Promyelocytic Leukemia Zinc Finger Protein. Medical Subject Headings (MeSH). 2026. Unique ID D000075722. http://id.nlm.nih.gov/mesh/2026/D000075722
  2. Promyelocytic Leukemia Zinc Finger Protein. In: Wikidata. https://www.wikidata.org/wiki/Q11705457