Chemicals and Drugs

Promegestone

A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.

Chemical Identity

Chemical Information

Molecular Formula
C22H30O2
Molecular Weight
326.5 g/mol
CAS Registry No.
34184-77-5
IUPAC Name
(8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
InChIKey
QFFCYTLOTYIJMR-XMGTWHOFSA-N
SMILES
CCC(=O)[C@]1(CC[C@@H]2[C@@]1(CCC3=C4CCC(=O)C=C4CC[C@@H]23)C)C
MeSH Unique ID
D011397
Source
PubChem CID 36709

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

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MeSH Record

Synonyms

9 entry terms
  • 17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione
  • Promestone
  • R-5020
  • R5020
  • RU-5020
  • RU5020
  • Surgestone
  • R 5020
  • RU 5020

MeSH Record

Aspects Covered

25 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analogs & derivatives, analysis, antagonists & inhibitors, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, economics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, urine.

MeSH Record

Indexing Annotation

D25-26

MeSH Record

History Note

91(86); was see under NORPREGNADIENES 1986-90; was R 5020 see under NORPREGNADIENES 1979-85

MeSH Record

Previous Indexing

  • Norpregnadienes (1975-1978)
  • Pregnanes (1968-1974)
  • Progestational Hormones (1966-1974)
  • Progestational Hormones, Synthetic (1975-1978)

MeSH Hierarchy

Tree Number

  1. D04w.210.500w.668w.651.443.680w

AMA Style

References

  1. National Library of Medicine. Promegestone. Medical Subject Headings (MeSH). 2026. Unique ID D011397. http://id.nlm.nih.gov/mesh/2026/D011397
  2. Promegestone. In: Wikipedia. https://en.wikipedia.org/wiki/Promegestone
  3. Promegestone. In: Wikidata. https://www.wikidata.org/wiki/Q7249694
  4. Promegestone. In: PubChem Compound. CID 36709. https://pubchem.ncbi.nlm.nih.gov/compound/36709