Chemicals and Drugs

Prokaryotic Initiation Factor-1

The smallest of the three prokaryotic initiation factors with a molecular size of approximately 8 kD. It binds near the A-site of the 30S subunit of RIBOSOMES and may play a role in preventing premature addition of aminoacyl-tRNA-linked PEPTIDE ELONGATION FACTOR TU to the ribosome during the initiation of a peptide chain (PEPTIDE CHAIN INITIATION, TRANSLATIONAL).

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

The smallest of the three prokaryotic initiation factors with a molecular size of approximately 8 kD. It binds near the A-site of the 30S subunit of RIBOSOMES and may play a role in preventing premature addition of aminoacyl-tRNA-linked PEPTIDE ELONGATION FACTOR TU to the ribosome during the initiation of a peptide chain (PEPTIDE CHAIN INITIATION, TRANSLATIONAL).

MeSH Record

Classification

Broader headings

Related Concepts

Knowledge Graph

Loading graph…

Drag nodes to rearrange; hover to trace links; click a node to open its page.

MeSH Record

Synonyms

11 entry terms
  • Initiation Factor IF-1
  • Peptide Initiation Factor IF-1
  • Peptide Initiation Factor-1, Prokaryotic
  • Prokaryotic Peptide Initiation Factor-1
  • IF-1, Initiation Factor
  • Initiation Factor IF 1
  • Initiation Factor-1, Prokaryotic
  • Peptide Initiation Factor 1, Prokaryotic
  • Peptide Initiation Factor IF 1
  • Prokaryotic Initiation Factor 1
  • Prokaryotic Peptide Initiation Factor 1

MeSH Record

Aspects Covered

30 allowable subheadings

Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.

MeSH Record

History Note

2003; for IF-1 use EUKARYOTIC INITIATION FACTOR-1 1990-2002

MeSH Record

Previous Indexing

  • Eukaryotic Initiation Factor-1 (1989-2002)
  • Peptide Initiation Factors (1978-2002)

MeSH Hierarchy

Tree Number

  1. D12.776w.835w.725w.934w.374w

AMA Style

References

  1. National Library of Medicine. Prokaryotic Initiation Factor-1. Medical Subject Headings (MeSH). 2026. Unique ID D039861. http://id.nlm.nih.gov/mesh/2026/D039861
  2. Prokaryotic Initiation Factor-1. In: Wikipedia. https://en.wikipedia.org/wiki/Bacterial_initiation_factor_1
  3. Prokaryotic Initiation Factor-1. In: Wikidata. https://www.wikidata.org/wiki/Q7249507