Structured Summary
Abstract
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
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Aspects Covered
30 allowable subheadings
Indexed with the subheadings administration & dosage, adverse effects, agonists, analysis, antagonists & inhibitors, biosynthesis, blood, cerebrospinal fluid, chemical synthesis, chemistry, classification, deficiency, drug effects, economics, genetics, history, immunology, isolation & purification, metabolism, pharmacokinetics, pharmacology, physiology, poisoning, radiation effects, standards, supply & distribution, therapeutic use, toxicity, ultrastructure, urine.
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History Note
72
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Previous Indexing
- Insulin (1966-1971)
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WK 802
AMA Style
References
- National Library of Medicine. Proinsulin. Medical Subject Headings (MeSH). 2026. Unique ID D011384. http://id.nlm.nih.gov/mesh/2026/D011384
- Proinsulin. In: Wikipedia. https://en.wikipedia.org/wiki/Proinsulin
- Proinsulin. In: Wikidata. https://www.wikidata.org/wiki/Q426173