Diseases

Progressive Bulbar Palsy

A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)

National Library of MedicineMedical Subject Headings2026

Structured Summary

Abstract

A motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)

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Broader headings

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MeSH Record

Synonyms

27 entry terms
  • Bulbar Palsy, Progressive
  • Bulbar Palsies, Progressive
  • Palsies, Progressive Bulbar
  • Palsy, Progressive Bulbar
  • Progressive Bulbar Palsies
  • Bulbar Palsy
  • Bulbar Palsy, Progressive, Of Childhood
  • Childhood Progressive Bulbar Palsy
  • Fazio-Londe Disease
  • Fazio-Londe Syndrome
  • Fazio-Londe's Disease
  • Fazio-Londe's Syndrome
  • Paralysis, Bulbar
  • Progressive Bulbar Palsy of Childhood
  • Bulbar Palsies
  • Bulbar Paralyses
  • Bulbar Paralysis
  • Disease, Fazio-Londe
  • Disease, Fazio-Londe's
  • Fazio Londe Disease
  • Fazio Londe Syndrome
  • Fazio Londe's Disease
  • Fazio Londe's Syndrome
  • Palsies, Bulbar
  • Palsy, Bulbar
  • Syndrome, Fazio-Londe
  • Syndrome, Fazio-Londe's

MeSH Record

Aspects Covered

35 allowable subheadings

Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, congenital, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.

MeSH Record

History Note

2000(1966)

MeSH Hierarchy

Tree Numbers

  1. C10w.574w.562w.300w
  2. C10w.668w.467w.300w

MeSH Record

NLM Classification

WL 310

AMA Style

References

  1. National Library of Medicine. Progressive Bulbar Palsy. Medical Subject Headings (MeSH). 2026. Unique ID D010244. http://id.nlm.nih.gov/mesh/2026/D010244
  2. Progressive Bulbar Palsy. In: Wikipedia. https://en.wikipedia.org/wiki/Progressive_bulbar_palsy
  3. Progressive Bulbar Palsy. In: Wikidata. https://www.wikidata.org/wiki/Q7248833