Structured Summary
Abstract
An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature graying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
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Synonyms
7 entry terms
- Hutchinson Gilford Progeria Syndrome
- Hutchinson-Gilford Progeria Syndrome
- Hutchinson-Gilford Syndrome
- Hutchinson Gilford Syndrome
- Hutchinson-Gilford Progeria Syndromes
- Progeria Syndrome, Hutchinson-Gilford
- Progeria Syndromes, Hutchinson-Gilford
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Aspects Covered
34 allowable subheadings
Indexed with the subheadings blood, cerebrospinal fluid, chemically induced, classification, complications, diagnosis, diagnostic imaging, diet therapy, drug therapy, economics, embryology, enzymology, epidemiology, ethnology, etiology, genetics, history, immunology, metabolism, microbiology, mortality, nursing, parasitology, pathology, physiopathology, prevention & control, psychology, radiotherapy, rehabilitation, surgery, therapy, urine, veterinary, virology.
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References
- National Library of Medicine. Progeria. Medical Subject Headings (MeSH). 2026. Unique ID D011371. http://id.nlm.nih.gov/mesh/2026/D011371
- Progeria. In: Wikipedia. https://en.wikipedia.org/wiki/Progeria
- Progeria. In: Wikidata. https://www.wikidata.org/wiki/Q213098